If you’re thinking about wrinkle relaxers, it’s easy to get overwhelmed by the options. Here’s a straightforward breakdown of the four most popular neurotoxins — Xeomin, Botox, Dysport, and Letybo — and where they work best.
Botox
Active Ingredient: Botulinum toxin type A (onabotulinumtoxinA)
Onset Time: 3–5 days
Duration: ~3–4 months
Diffusion: Medium — offers precise targeting with controlled spread
FDA Approval: Approved in the U.S. since 2002
Best For: Glabella (frown lines), crow’s feet, forehead lines
Dysport
Active Ingredient: Botulinum toxin type A (abobotulinumtoxinA)
Onset Time: 1–3 days (fastest onset)
Duration: ~3–4 months
Diffusion: High — spreads more easily, which is helpful in larger areas
FDA Approval: Approved in the U.S. since 2009
Best For: Forehead, glabella, and other broader treatment zones
Xeomin
Active Ingredient: Botulinum toxin type A (incobotulinumtoxinA)
Onset Time: 3–4 days
Duration: ~3–4 months
Diffusion: Low — highly targeted for precision
Purity: “Naked” toxin – no accessory proteins (less risk of resistance)
FDA Approval: Approved in the U.S. since 2011
Best For: Glabella, crow’s feet, smaller or high-precision areas
Letybo
Active Ingredient: Botulinum toxin type A (developed in Korea)
Onset Time: 3–4 days
Duration: ~3–4 months (ongoing clinical data)
Diffusion: Medium — smooth, even spread
Purity: Highly purified formulation
FDA Approval: Approved in South Korea (2022), expanding globally
Best For: Forehead, crow’s feet, glabella — ideal for soft, natural-looking results
Key Takeaways:
Botox is the classic go-to for most facial areas, offering predictable, long-lasting results.
Dysport kicks in fast and spreads more easily, making it ideal for broader zones like the forehead.
Xeomin delivers precise, clean results and is preferred when minimizing the risk of resistance is important.
Letybo is the emerging favorite for a smooth, K-beauty inspired finish, especially in high-movement areas like the forehead and eyes.
Want help choosing the right one for you? Book a consultation and we’ll guide you based on your features, preferences, and beauty goals 💉✨