PRP is widely popular amongst various medical fields such as dermatology, orthopedics, and dentistry due to its rich reservoir of growth factors, facilitating rapid healing. However, PRP needs external anticoagulants, which could interfere with the release of growth factors tied to the clotting process.
Platelet-rich fibrin (PRF) is the next generation of platelet-rich concentrate in comparison to Platelet-rich plasma (PRP). PRF was engineered to eliminate the need for external anticoagulants further reducing risks. Its preparation involves a faster centrifugation process to separate blood layers before clot formation. The resulting fibrin matrix ensures a slower and more prolonged release of growth factors compared to PRP. This advancement enhances the therapeutic potential of PRF for tissue regeneration and growth stimulation especially in bone regeneration, wound healing, improving scar appearance, and stimulating hair growth.